Giles Willis / Self 
Max Greenfield / David
Hollis Sasser / Self - Giles' Childhood Friend
Josh Caras / Brian
Brenda Davis / Self - Mayor of Stamps
Charlie Shotwell / Young Brian
Brett Eldredge / Self - Guest
Iain Armitage / Youngest Brian
Sarah Snook / Lori
Veronica Cabrera-Moreno / Self - Creator, Art Bus
Norberto Moreno / Self - Roni's Husband
Sadie Sink / Young Lori
Joshua Moreno / Self - Roni's Son, 10
Olivia Kate Rice / Youngest Lori
Brigette Lundy-Paine / Maureen
Noe Moreno / Self - Roni's Son, 16
Carlos Silva / Self - Chair, East Aldine Art Council
Shree Crooks / Young Maureen
Eden Grace Redfield / Youngest Maureen
Noah Herrera / Self - Art Bus Student
Julia Paige-Herrera / Self - Art Bus Student
Robin Bartlett / Erma
Joe Pingue / Uncle Stanley
Marisela Rodriguez / Self - Roni's Friend
A.J. Henderson / Grandpa Walls
Jay Leno / Self - Guest
Dominic Bogart / Robbie
Jaco Caraco / Self - Musician
Chris Gillett / Mr. Thomson
Jessi Collins / Self - Vocalist
Lester Estelle / Self - Musician
Tessa Mossey / Tiffany
Brenda Kamino / Mrs. Lehocky
Jason Halbert / Self - Band Leader
Marian Massaro / Announcer
Vlasta Vrana / Mr. Lehocky
Andrew Shaver / Dr. Taylor
Kyle Whalum / Self - Musician
Sandra Flores / Miss Kelly
Francesca Barcenas / Nurse
Bianca Bellange / Nurse
Izabel Kerr / Nurse
Darrin Baker / Pool Manager
Kyra Harper / Miss Bivens
Sarah Camacho / Student
Alanna Bale / Student
Ray Adams / Welch Daily News Operator
John Mullins / Welch Daily News Operator
Sabrina Campilii / Brian's Wife
Ross Partridge / Cab Driver
Jeannette Walls / Self
Rose Mary Walls / Self
Brian Walls / Self
Lori Walls / Self
Rex Walls / Self (archive footage)
Tyrone Benskin / Ronnie
Charlie Guyon / Baby Maureen
Noemie Guyon / Baby Maureen
Hamza Haq / Intern
Philippe Hartmann / NYC Deli Patron
Samantha Hodhod / Assistant
Nathaly Thibault / Business Woman
Kenny Wong / Restaurant Manager
John Robert Woodlock / Waiter