Billy Porter / Randy
Carmen Ejogo / Dr. Batiste
Donna Hanover / Debbie Carmichael
Merwin Mondesir / Glenn
Una Kay / Helen
Sonia Benezra / Aunt Sonya
Marcia Bennett / Nurse Stein
HoJo Rose / ER Doctor
Jane Wheeler / Karen
David Julian Hirsh / Barton
Marguerite Kinh / Mrs. Lee
Arthur Holden / Piano Player
Maurizio Terrazzano / Tom
Rachelle Lefevre / Holly
Erika Rosenbaum / Merry
Charles Rosenblum / Coffee Vendor
Victoria Sanchez / Young Mother
Scott Faulconbridge / Man in Front Row
Budd Mishkin / NY1 Reporter
Carmen Echeverria / Young Girl
Gianpaolo Venuta / Young Guy
Nicholas Haze / Waiter
Ruth Chiang / Nurse Woo
Kevin Ryder / Bartender
Andy Bradshaw / Security Guard #1
Robert Newton Brown / Security Guard #2
Bill Corday / Meek Man
Jennifer Seguin / Young Woman
Lindsay Owen Pierre / Friend
David Schaap / Man with Head Injury
Lynne Adams / Head ER Nurse
Kathleen Mackey / Heather
Donna Giaimo / Singing Nun of the Daughters of St. Paul
Fay Josephine Pele / Singing Nun of the Daughters of St. Paul
Bridget Charles Ellis / Singing Nun of the Daughters of St. Paul
Mary R.G. Grissom / Singing Nun of the Daughters of St. Paul
Kathryn J. Hermes / Singing Nun of the Daughters of St. Paul
Bernadette M. Reis / Singing Nun of the Daughters of St. Paul
Margaret Timothy Sato / Singing Nun of the Daughters of St. Paul
Patricia C. Shaules / Singing Nun of the Daughters of St. Paul
Nancy M. Usselmann / Singing Nun of the Daughters of St. Paul
Christina M. Wegendt / Singing Nun of the Daughters of St. Paul
Gabriella Palminteri / Girl in Red Coat
James Callaghan / Extra
Isabelle Champeau / Party Guest
Lucinda Davis / Nurse Gomez
Anthony Ferriso / Santa Kid #2
Loren Ferriso / Santa Kid
Francesco Giannini / Family member
Chantal Lonergan / Joy
Dante Palminteri / Boy in Hospital
Adrianne Richards / Nurse Kline
Derek Schnobb / Boy
Robin Williams / Charlie Boyd /  The Priest

Tony Calabretta / Dispatcher
James Bradford / Captain
Tedd Dillon / Stranger
Matt Holland / Parking Lot Cop
Dennis St John / Gregor
Michel Perron / Giannelli
Flint Eagle / Sheriff
Arthur Holden / Forensics Officer
Desmond Campbell / Police Station Officer
Jean-Marc Piché / Cab Driver
Mike Chute / Prison Guard
Pierre Leblanc / Gas Station Attendant /  Fenster
Victoria Sanchez / Police Translator
Noel Burton / Coroner
Daniel Skorzewski / Construction Site Cop
Peter Cox / Red Neck
Goûchy Boy / Lucifer
Griffith Brewer / Homeless Man
Eric Paré / Security Nightguard
Liz MacRae / Reporter (voice)
Mark Trafford / Radio Newscaster (voice)
John Canoe / Tribal Deputy

Richard Zeman / Lt. Carl Hanson
Olivia Birkelund / Lindsay Rubin
Gary Swanson / Alan Rubin
James Bulleit / Train Engineer
Frank Fontaine / Grandfather
Zena Grey / Granddaughter
Daniel Brochu / N.Y.U. Student
Desmond Campbell / Taxi Inspector
Christian Veliz / Chris
Mercedes Gómez / Ortiz's Mother
Mary Hammett / Girlfriend in Nightclub
Amanda Gay / Girl in Nightclub
Steve Adams / Gas Worker
Larry Day / Gas Worker
Burke Lawrence / Police Instructor
Terry Simpson / Cop in Apartment
Eric Davis / Cop in Apartment
Arthur Holden / Bookstore Clerk
Yahsmin Daviault / Rhyme's Sister
Keenan Macwilliam / Rhyme's Niece
David Warshofsky / Amelia's Partner
Mateo Gómez / Hot Dog Vendor
Ted Whittall / Ortiz's Assistant
Peter Michael Dillon / Homicide Detective
Jonathan Stark / Male Detective
Fulvio Cecere / Forensics Expert
Hal Sherman / Fingerprint Cop
Russell Yuen / Forensics Worker
Andy Bradshaw / Uniform Cop
Jean-Marc Bisson / Rescue Worker
Christopher Bregman / Rescue Worker
Sonya Biddle / Nurse