Amber Valletta / Celine
Cheryl Bartel / Ginger
Tim Maculan / Terrence
Jackie Sandler / Bartender
Evgeniy Lazarev / Mr. Dzerzhinsky
Kumar Pallana / Indian Restaurant Owner
Philip Perlman / Phil
Gary Riotto / Drug Dealer
Michelle Krusiec / Dr. Kang
Margie Loomis / Old Biddy #1
Linda Porter / Old Biddy #2
Edward Edwards / Antique Dealer
Louis Giambalvo / Pharmacist
Tracey Walter / Pharmacy Customer
John Hamburg / Mr. Friedman
Christina Kirk / Mrs. Friedman
Jenette Goldstein / Moderator
Leyna Nguyen / Female Newscaster
Chuma Gault / Mailroom Guy\
Jim Castillo / Weatherman
Michael Fahn / Sneezer on Train
Roberta R. Deen / Caterer
Christopher Doyle / Tavern Bartender
Christine La Fontaine / Don Piper Fan #1
Joey Banks / Police Officer
Geraldine Hughes / Receptionist
Picasso / Little Dick
Guiles / Little Dick
Bugsy / Little Dick
Maestro / Little Dick
Will Blomquist / College Student on Subway
Danny DeVito / Narrator (voice)
Azizah Rowen / Barista
Larry Vigus / Man on the Street

Lindsay Burdge / Madeleine (segment "The Birthday Party")
Valeria Chavez / Party Goer (segment "The Birthday Party")
Jay Chirinos / Party Goer (segment "The Birthday Party")
Laura G. Chirinos / Party Goer (segment "The Birthday Party")
Brooklyn Hatrak / Party Goer (segment "The Birthday Party")
April Hernandez / Party Goer (segment "The Birthday Party")
Clayton Jackson / Party Goer (segment "The Birthday Party")
Ozzy Villazon / Party Goer (segment "The Birthday Party")
Tallulah / Party Goer (segment "The Birthday Party")
Andrea Peeler / Party Goer (segment "The Birthday Party")
Jonathan Lansky / Party Goer (segment "The Birthday Party")
Casey Adams / Paul (segment "Don't Fall")
Breeda Wool / Gretchen (segment "Don't Fall")
Angela Trimbur / Jess (segment "Don't Fall")
Morgan Krantz / Jay (segment "Don't Fall")
Christina Kirk / Cora (segment "Her Only Living Son")
Kyle Allen / Andy (segment "Her Only Living Son")
Mike Doyle / Chet (segment "Her Only Living Son")
Brenda Wehle / Principal Jenks (segment "Her Only Living Son")
Morgan Peter Brown / Mr. Dayton (segment "Her Only Living Son")
Lisa Renee Pitts / Kelly Withers (segment "Her Only Living Son")
Lisa Costanza / Female Onlooker (segment "Her Only Living Son")
Ruben Pla / Male Patron (segment "Her Only Living Son")
Curt Cornelius / Dr. Roman (segment "Her Only Living Son")
Bruce M. Stockert / Man in Background (segment "Her Only Living Son")(uncredited)
Joe Swanberg / Singing Panda (segment "The Birthday Party")