Tissa Willis / Rose
Bishop Dee / Charles
Darryl Blalock / Rico
Cinderella Graham / Jules

Bette Rae / Elizabeth
Hawthorne James / Bill
Mel Brooks / Tom (voice)
Rosemary Clooney / Gladys (voice)
Dominick Dunne / Jeff (voice)
Ben Stiller / Barry (voice)
Eric Stoltz / Don (voice)
Tory Christopher / Drunken KACL Employee
Aruni Devi Hansen / Diner Patron
Moose / Eddie

Kellita Smith / Tracy
Trish Penix / Sharice
Kenneth Whack / Kenji
Lamont Johnson / Loudmouth
Shirley Hemphill / Sister Claus
Tony Cox / Mr. Johnson
Tonya Reneé Banks / Mrs. Johnson
Valdez Flagg / Stage Manager
BeBe Winans / BeBe Winans
CeCe Winans / CeCe Winans

Douglas Spain / Manuel (segment "Caught in the Fever")
Luke Perry / Boomer (segment "Empty")
Peter Dobson / Chaz (segment "Empty")
Mario Van Peebles / Turner (segment "Homecoming Day")
Melvin Van Peebles / Vernon (segment "Homecoming Day")
Cicely Tyson / Maggie (segment "Homecoming Day")
Derek Basco / Lyle (segment "Gold Mountain")
Phillip Wong / Phil (segment "Gold Mountain")
Ernie Lee Banks / Wino (segment "Gold Mountain")
Judy Kerr / Mrs. White (segment "Gold Mountain")
Steven Meek / Yuppie Guy (segment "Gold Mountain")
Dwayne Barnes / Black Customer (segment "Gold Mountain")
Irene Olga López / Mrs. Rodriguez (segment "Caught in the Fever")
Seidy Lopez / Alicia (segment "Caught in the Fever")
Lupe Ontiveros / Mother (segment "Caught in the Fever")
Jermaine Hopkins / Young Black Man (segment "Caught in the Fever")
Norman Duarte / Young Latino Youth (segment "Caught in the Fever")
Wendy L. Walsh / Reporter (segment "Caught in the Fever")
Carlos Gómez / Ocampo (segment "Empty")
Lucy Liu / Tiffany (segment "Empty")
Dean Norris / Kalena (segment "Empty")
Sarah Rayne / Heather (segment "Empty")
Moira Walley-Beckett / Paula (segment "Empty")
Kimberly Oja / Dawn (segment "Empty")
Byron Minns / Customer #1 (segment "Empty") /  Johnny (segment "Homecoming Day")
J.D. Hall / Customer #2 (segment "Empty")
Bebe Drake / Black Kid's Mother (segment "Empty")
Angelle Brooks / Linda (segment "Homecoming Day")
Lou Myers / George (segment "Homecoming Day")
Paula Jai Parker / Lisa (segment "Homecoming Day")
Clifton Powell / Steve (segment "Homecoming Day")
Lee Weaver / Odelle (segment "Homecoming Day")
Hawthorne James / Boone (segment "Homecoming Day")
Nigel Thatch / Raymond (segment "Homecoming Day")
Patricia Hodges / Cheryl (segment "Homecoming Day")
Dana Chelette / Young Nate (segment "Homecoming Day")
Marlow Wyatt / Young Black Woman (segment "Homecoming Day")
JoNell Kennedy / Young Maggie (segment "Homecoming Day")
Mykal Wayne Williams / Looter (segment "Homecoming Day")
Pat DeSilva / Pat DeSilva
Bryan Jenkins / Bryan Jenkins
Marston Fobbs / Teen Looter (segment "Homecoming Day")
Paula Vasquez / Female Shopper
D. Danny Warhol / Diner Patron (segment "Empty")