Billy Porter / Randy
Carmen Ejogo / Dr. Batiste
Donna Hanover / Debbie Carmichael
Merwin Mondesir / Glenn
Una Kay / Helen
Sonia Benezra / Aunt Sonya
Marcia Bennett / Nurse Stein
HoJo Rose / ER Doctor
Jane Wheeler / Karen
David Julian Hirsh / Barton
Marguerite Kinh / Mrs. Lee
Arthur Holden / Piano Player
Maurizio Terrazzano / Tom
Rachelle Lefevre / Holly
Erika Rosenbaum / Merry
Charles Rosenblum / Coffee Vendor
Victoria Sanchez / Young Mother
Scott Faulconbridge / Man in Front Row
Budd Mishkin / NY1 Reporter
Carmen Echeverria / Young Girl
Gianpaolo Venuta / Young Guy
Nicholas Haze / Waiter
Ruth Chiang / Nurse Woo
Kevin Ryder / Bartender
Andy Bradshaw / Security Guard #1
Robert Newton Brown / Security Guard #2
Bill Corday / Meek Man
Jennifer Seguin / Young Woman
Lindsay Owen Pierre / Friend
David Schaap / Man with Head Injury
Lynne Adams / Head ER Nurse
Kathleen Mackey / Heather
Donna Giaimo / Singing Nun of the Daughters of St. Paul
Fay Josephine Pele / Singing Nun of the Daughters of St. Paul
Bridget Charles Ellis / Singing Nun of the Daughters of St. Paul
Mary R.G. Grissom / Singing Nun of the Daughters of St. Paul
Kathryn J. Hermes / Singing Nun of the Daughters of St. Paul
Bernadette M. Reis / Singing Nun of the Daughters of St. Paul
Margaret Timothy Sato / Singing Nun of the Daughters of St. Paul
Patricia C. Shaules / Singing Nun of the Daughters of St. Paul
Nancy M. Usselmann / Singing Nun of the Daughters of St. Paul
Christina M. Wegendt / Singing Nun of the Daughters of St. Paul
Gabriella Palminteri / Girl in Red Coat
James Callaghan / Extra
Isabelle Champeau / Party Guest
Lucinda Davis / Nurse Gomez
Anthony Ferriso / Santa Kid #2
Loren Ferriso / Santa Kid
Francesco Giannini / Family member
Chantal Lonergan / Joy
Dante Palminteri / Boy in Hospital
Adrianne Richards / Nurse Kline
Derek Schnobb / Boy
Robin Williams / Charlie Boyd /  The Priest

Russell Hornsby / Shill
Aldis Hodge / Leafletter
Debi Mazar / Matron
Mena Suvari / Whore
Jeffrey Combs / Desk Clerk
Barry Cullison / Pawn Shop Customer
George Wendt / Pawn Shop Owner
Marcus Thomas / Window Man
Lionel Mark Smith / Pimp
Julia Stiles / Glenna
Patricia Belcher / Woman on Subway
Wren T. Brown / Preacher
Bruce A. Young / Policeman
Dylan Walsh / Interrogator
Bokeem Woodbine / Prisoner
Jack Wallace / Chaplain
Mike Saad / Library Guard

Vinnie Jones / Keith Ritson
Tony Lo Bianco / Jack Licavoli
Laura Ramsey / Ellie O'Hara
Steve Schirripa / Mike Frato
Paul Sorvino / Tony Salerno
Mike Starr / Leo 'Lips' Moceri
Marcus Thomas / William 'Billy' McComber
Vinny Vella / Frank Brancato
Brian Balzerini / Valet
Cody Christian / Young Danny Greene
Dante Wildern / Young Billy McComber
Sean O'Reilly / Tony Lupero
Vincent Angelini / Vic Centauro
Grant R. Krause / Tommy Sinito
Jeff Chase / Joe Buka
Jim Porterfield / Stan Gilroy
Nina Kircher / Merke's Secretary
Loren Bass / Macleish
Richard Jewell / Agent Mike Malloy
John Seibert / Steve Marshak
Greg Trzaskoma / Theatrical Grille Bartender
John Hawkinson / Detective Podorski
Jimmy Doom / Biker Bill
Lise Lacasse / Mrs. Shaughnessy
Arthur Cartwright / Leg Breaker
Joey Albright / Garbage Man
Walter Lindsey Jr. / Furniture Mover
Douglas Minckiewicz / Kevin McKiernan
Robert Skrok / Brendan Calhoun
Ruth Crawford / Mrs. Birns
Steven Goldsmith / Martin
Renell Michael White / Billy Cox
Jeff Wolfe / Undercover Cop
John Duffey Leo / Geoffrey Greene
Al Corley / TV Reporter
Michael Brian Ogden / Julius
Trevor Callaghan / Cleveland Kid